Merck Aktie 10683053 / US58933Y1055
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28.10.2025 12:56:33
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Merck Says WELIREG,LENVIMA Combination Therapy Meets PFS Goal In Phase 3 Kidney Cancer Trial
(RTTNews) - Merck & Co Inc. (MRK) and Eisai oCo. Ltd (ESALY.PK) on Tuesday said that the Phase 3 LITESPARK-011 trial evaluating Merck's WELIREG in combination with Eisai's LENVIMA met one of its primary endpoints of progression-free survival (PFS) in patients with advanced renal cell carcinoma (RCC) whose disease had progressed on or after treatment with anti-PD-1/L1 therapy.
The combination demonstrated a statistically significant and clinically meaningful improvement in PFS compared with cabozantinib at an interim analysis. Overall survival (OS), the study's other primary endpoint, will be evaluated at a future analysis.
Merck and Eisai said the safety profiles of WELIREG and LENVIMA were consistent with previous studies of the individual therapies, and no new safety signals were observed.
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